20世纪初，北极探险家斯蒂芬森（Vilhjalmur Stefansson）曾连续五年内只吃肉食，这意味着他的饮食由约80％的脂肪和20％的蛋白质组成。二十年后的1928年，他在纽约市贝尔维尤医院再做了一次为期一年的只吃肉食的实验。
斯蒂芬森想反驳那些认为如果人类只吃肉就无法生存的人。但不幸的是，无论是在北极还是纽约，当他只吃瘦肉，不要脂肪，他很快就生了病。借此，他提出了“蛋白质中毒”这一病症，绰号为“兔子饥饿症”。
不过，当他降低蛋白质摄入量并且增加了脂肪的摄入后，症状也就消失了。事实上，他从北极回到纽约，恢复美国典型的高蛋白饮食生活时，就发现自己的健康状况恶化，因此他选择了继续其低碳水化合物，高脂肪和高蛋白的饮食习惯，直至他83岁逝世。
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